The Metabolic Effects of the Acetic and Propionic Acid Analogs of Thyroxine
نویسنده
چکیده
Within the last six years the identification of several new substances with thyroid hormone-like activity has led to a re-evaluation of the physiological role of thyroxine and of its analogs and derivatives. Since its isolation in 1915 (1) thyroxine was considered the most biologically potent of all simple thyroactive materials until the discovery by Gross and Pitt-Rivers (2) and by Roche, Lissitzky and Michel (3) that 3,5,3'-triiodo-L-thyronine (trit) was four to five times more effective in both animals and man. The acetic acid analogs of thyroxine and trit have been actively investigated since 1953 (4). Thibault and Pitt-Rivers (5-7) described a unique action of these compounds in that they produced an increased oxygen consumption in vitro without previous injection into animals. The maximum effects were reached in 15 minutes and disappeared after 90 minutes. A single injection of these drugs into thyroidectomized rats increased oxygen consumption within two hours. Although these studies have not been confirmed (8, 9), they resulted in the postulate that this might be the form of the thyroid hormone utilized at the tissue level. This suggestion became even more attractive when these substances were isolated from tissues and homogenates (10-17). Other studies in man have suggested a dissociation of responses to those drugs (18-25). In patients with hypothyroidism, (19, 21) it was noted that on small doses of the acetic acid analogs the serum cholesterol level fell, the nitrogen and
منابع مشابه
The metabolic effects of the acetic and propionic acid analogs of thyroxine and triiodothyronine.
متن کامل
Application of anaerobic digestion products of municipal solid food wastes in treating wastewaters
Anaerobic digestion is the breakdown of biodegradable organic material by microorganisms in the absence of oxygen or in an oxygen-starved environment.This technology is superior to the landfilling and also the aerobic composting. The aim of the present study was to examine whether the effluent Volatile Fatty Acids from the anaerobic acidogenesis of the food waste can be used du to its high valu...
متن کاملPropionic acid extraction in a microfluidic system: simultaneous effects of channel diameter and fluid flow rate on the flow regime and mass transfer
In this work, extraction of propionic acid from the aqueous phase to the organic phase (1-octanol) was performed in T-junction microchannels and effects of channel diameter and fluid flow rate on the mass transfer characteristics were investigated. The two-phase flow patterns in studied microchannels with 0.4 and 0.8 mm diameters were observed. Weber number and surface-to-volume ratio were ca...
متن کاملEffect of Whey Permeate and Yeast Extract on Metabolic Activity of Bifidobacterium Animalis Subsp. Lactis Bb 12
In fermented products containing Bifidobacteria, factors such as organic acid concentration and b-galactosidase activity are important in the development of flavor and texture of final products. Both the process conditions and medium components have significant effects on fluctuation of such factors. The effects of whey permeate powder and yeast extract concentrations, as nitrogen sources was i...
متن کاملImpact of Propionic Acid on Liver Damage in Rats
Propionic acid (PA) is a short chain fatty acid, a common food preservative and metabolic end product of enteric bacteria in the gut. The present study was undertaken to investigate the effect of PA on liver injury in male rats. Male western albino rats were divided into two groups. The first group served as normal control, the second was treated with PA. The activities of serum hepatospecific ...
متن کامل